Potential Combination of Hesperetin and Vitamin C based on PLGA (Poly Lactic-co-Glycolic Acid) on Healing Fragility Fracture in Osteoporosis Patients

Journal of Clinical Orthopaedics | Vol 5 | Issue 2 |  July-Dec 2020 | page: 25-29 | Kadek Mercu Narapati Pamungkas, Putu Itta Sandi Lesmana Dewi, Made Agus Maharjana

Author: Kadek Mercu Narapati Pamungkas [1], Putu Itta Sandi Lesmana Dewi [1], Made Agus Maharjana [2]

[1] Bachelor of Medicine and Medical Doctor Profession Study Program of Udayana University, Indonesia
[2] Department of Orthopedics and Traumatology, Faculty of Medicine, Udayana University- Sanglah General Hospital, Indonesia

Address of Correspondence
Dr. Kadek Mercu Narapati Pamungkas,
Bachelor of Medicine and Medical Doctor Profession Study Program of Udayana University, Indonesia


Background: Osteoporosis is a degenerative bone disease that occurs around 15.3% in Southeast Asia. Osteoporosis patients are very vulnerable and often experience fragility fractures. Until now, the treatment of fragility fractures, namely pharmacological and operative therapy, has not been optimal in restoring bone density and allowing recurrence.
Purpose: The aim of this research is to find the modality of therapy fragility fracture that can prevent and improve the condition. Methods: This literature was prepared using literature review methods being sourced from valid medical journals such as published in PubMed, Research Gate, and Google Scholar.
Results: Hesperetin in citrus fruit can inhibit RANKL-induced osteoclastogenesis, reduce the amount and size of F-actin, and accelerate fracture healing in vivo. Vitamin C, which is also present in citrus fruit, has an important role in the synthesis of the triple helix collagen and shows better fracture healing at week 4. PLGA has a role in more specific drug delivery, preventing rapid clearance, biodegradable, increasing calcium deposition, and extending drug release time.
Conclusion: Combination of Hesperetin and PLGA-based vitamin C can be promising therapies in the healing and prevention of fragility fractures. Suggestion: The author suggests conducting further research to determine side effects, proper dosage, and drug administration.
Keywords: Fragility Fracture, Hesperetin, PLGA, Vitamin C


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How to Cite this article: Pamungkas KMN, Dewi PISL, Maharjana MA. Potential Combination of Hesperetin and Vitamin C based on PLGA (Poly Lactic-co-Glycolic Acid) on Healing Fragility Fracture in Osteoporosis Patients. Journal of Clinical Orthopaedics July-Dec 2020;5(2):25-29.

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