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Surgical site infection following spine surgery

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:38-44 | Dr. Kshitij Chaudhary, Dr. Gautam Zaveri


Author: Kshitij Chaudhary [1], Gautam Zaveri [1]

[1] Sir HN Reliance Foundation Hospital and Research Center, Mumbai
[2] Department of Spine Surgery, Jaslok Hospital & Research Centre.

Address of Correspondence
Dr. Kshitij Chaudhary
Sir HN Reliance Foundation Hospital and Research Center, Mumbai
E-mail: chaudhary.kc@gmail.com


Abstract

Surgical site infection in spine surgery is a devastating complication not only from a medical perspective but also from an economic standpoint. Early detection and debridement are necessary, especially if one has to retain the instrumentation. In late infection, if the fusion is confirmed, implant exit can be performed to better treat the infection. The current review focuses on the decision making in Surgical site infections in Spine Surgery
Keywords: Surgical site infection, Spine Surgery, implant


References

1. Fang C, Wong T-M, To KK, Wong SS, Lau T-W, Leung F. Infection after fracture osteosynthesis – Part II. J Orthop Surg. 2017;25(1):230949901769271.
2. Falagas ME, Karageorgopoulos DE. Pandrug Resistance (PDR), Extensive Drug Resistance (XDR), and Multidrug Resistance (MDR) among Gram‐Negative Bacilli: Need for International Harmonization in Terminology. Clin Infect Dis. 2008;46(7):1121-1122.
3. Willenegger H, Roth B. [Treatment tactics and late results in early infection following osteosynthesis]. Unfallchirurgie 1986;12:241–246.
4. Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with
fracture-fixation devices. Injury 2006;37:S59–S66.
5. W.J. Metsemakers et al. Infection after Fracture Fixation: Current surgical and microbiological concepts. Injury, Int. J. Care Injured 49 (2018) 511–522
6. Steinmetz et al. Infection after Fracture Fixation. EFORT Open Rev 2019; 4: 468-475.


How to Cite this article: Chaudhary K, Zaveri G. Surgical site infection following spine surgery. Journal of Clinical Orthopaedics July-Dec 2019;4(2):38-44.

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Fracture Related Surgical Site Infections

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:33-37 | Dr. Aditya Menon, Vikas Agashe, Dr. Camilla Rodrigues, Dr. Anjali Shetty, Dr. Rajeev Soman, Dr. Bimal Mody, Dr. Ayesha Sunavala


Author: Aditya Menon [1], Vikas Agashe [1], Camilla Rodrigues [1],  Anjali Shetty [1], Rajeev Soman [1], Bimal Mody [1], Ayesha Sunavala [1]

[1] PD Hinduja National Hospital, Mahim

Address of Correspondence
Dr. Aaditya Menon,
PD Hinduja National Hospital, Mahim
Email: docmenon83@gmail.com


Abstract

Surgical site infections following operative treatment of fractures are challenging because of the presence of implants and the problem of fracture healing. The senior author (VA) recommends a 6 legged table concept for good outcomes when dealing with surgical site infections in orthopaedics. This includes early detection of infection, radical debridement, local measures to control wound infection, early soft tissue cover, provision of adequate stability and targeted antibiotics for adequate duration.
Keywords: Surgical site infection, fractures, implant.


References

1. Fang C, Wong T-M, To KK, Wong SS, Lau T-W, Leung F. Infection after fracture osteosynthesis – Part II. J Orthop Surg. 2017;25(1):230949901769271.
2. Falagas ME, Karageorgopoulos DE. Pandrug Resistance (PDR), Extensive Drug Resistance (XDR), and Multidrug Resistance (MDR) among Gram‐Negative Bacilli: Need for International Harmonization in Terminology. Clin Infect Dis. 2008;46(7):1121-1122.
3. Willenegger H, Roth B. [Treatment tactics and late results in early infection following osteosynthesis]. Unfallchirurgie 1986;12:241–246.
4. Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with
fracture-fixation devices. Injury 2006;37:S59–S66.
5. W.J. Metsemakers et al. Infection after Fracture Fixation: Current surgical and microbiological concepts. Injury, Int. J. Care Injured 49 (2018) 511–522
6. Steinmetz et al. Infection after Fracture Fixation. EFORT Open Rev 2019; 4: 468-475.


How to Cite this article: Menon A, Agashe V, Rodrigues C, Shetty A, Soman R, Mody B, Sunavala A. Fracture Related Surgical Site Infections. Journal of Clinical Orthopaedics July-Dec 2019;4(2):33-37.

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Surgical Site Infections in Orthopaedics: An Introduction

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:5-6 |  Dr. Gautam Zaveri


Author: Dr. Gautam Zaveri [1]

[1] Department of Spine Surgery, Jaslok Hospital & Research Centre

Address of Correspondence
Dr. Gautam Zaveri,
Department of Spine Surgery, Jaslok Hospital & Research Centre
E-mail: gautamzaveri1969@gmail.com


Surgical Site Infections in Orthopaedics: An Introduction

Surgical site infections (SSIs) are defined as infections of tissues, organs or spaces exposed by surgeons during the performance of an invasive procedure, that occur within 30 days of surgery or within 1 year of surgery involving implants[1]. In the USA, SSIs are ranked third amongst all reported cases of inpatient nosocomial infections [2,3]. Approximately, 5,00,000 SSIs are reported in the USA every year (2.8 per 100 operations) [4], accounting for 16% of nosocomial infections in all hospitalized patients [5]. Between 30,000- 35,000 SSIs are reported annually in the USA following the performance of an orthopaedic invasive procedure[6]. In a developing nation such as India where surgeries are performed in operating theatres with varying standards and practice of asepsis, the incidence of SSIs is estimated to be many folds higher. As our horizons continue to expand, and we are called upon to perform more complex procedures on patients who are elderly, immuno-compromised and with multiple medical comorbidities, the incidence of SSIs is likely to rise further.
Orthopaedic surgeons have always dreaded SSIs. They compromise the outcome of an otherwise successful surgery resulting in increased suffering, disability, morbidity and mortality and may often compromise the eventual outcome. Besides SSIs result in more extended hospitalization, increased direct and indirect costs, loss of work hours and even job loss. Whitehouse et al. performed a case-controlled study to look at the outcomes following SSIs in orthopaedics [7]. They reported an increase in hospital stay by a median of 2 weeks per patient, approximately double rehospitalization rates and increased healthcare costs by more than 300%. They also found patients with SSIs to have substantially higher physical limitations and significant reductions in health-related quality of life.
Early detection of wound infection requires careful vigilance by the operating team. Pain that is out of proportion to the nature of surgery, fever and difficulty in moving the limb are early signs of infection that may appear even before the surgical site shows signs of infection such as local warmth, tenderness, redness, shininess, oedema, induration and discharge. Laboratory tests and x-rays are of limited use in diagnosing an early infection. In the immediate postoperative setting, an MRI scan is also of limited use because soft tissue hyperintensities and fluid collections are typically seen within the wound at this time. Obtaining a tissue sample to isolate an organism is vital in planning the subsequent treatment.
SSIs in orthopaedics is especially challenging because of the large muscle bulk, the problem of persistence of infection within the bone and the formation of biofilms on dead bone and implants. The treatment of an established SSI entails source control, coupled with targeted anti-biotics. Source control involves drainage of purulent material, physical debride-ment of dead and infected tissue including bone, and copious irrigation of the wound. Implants can be retained, removed or replaced based on the progress of bone healing, the formation of biofilms and the fixation of the implant within the bone. A variety of techniques can be used to obtain local control of infection including antibiotic-loaded cement beads, biocomposites like Stimulan coupled with antibiotics or application of silver nitrate solution. In severe infections, especially in the presence of implants, primary wound closure is avoided and negative pressure wound therapy is used to obtain a reduction in local infection, to promote granulation and healing of the wound. Occasionally, especially for extremity wounds, a flap may be required to cover exposed implant/ bone/ joints/ tendons / nerves. Antibiotics must be targeted to the organism isolated and administered for prolonged periods (8 to 12 weeks or even longer). Rifamycins are active against biofilms of staphylococci and fluoroquinolones against those of gram-negative bacilli.
The endpoint of stopping antibiotics and declaring complete eradication of infection has not yet been clearly outlined in the literature. No single investigation or clinical sign in isolation can help determine the healing of the infection. Clinical improvement wound healing, reduction in CRP, ESR and Total WBC count, MRI evidence of reduction in soft tissue hyperintensities, fluid collection and bone marrow oedema, fatty conversion of bone marrow with fusion, and a negative bone scan are some of the features of a healed infection.
In spite of considerable improvements in the operating room environment, surgical techniques and aseptic practices, SSIs continue to constitute a significant challenge for the medical team and healthcare institutions. A multipronged approach involving surveillance, antimicrobial prophylaxis, eradication of carrier status, infection control program-mes and education is vital to reduce the risk of SSI. The old adage, “An Ounce of Prevention is better than a Pound of Cure” is aptly suited to the problem of surgical site infections in orthopaedics.


References

1. Guideline for Prevention of Surgical Site Infection (2017). Centre for disease control and prevention. https://www.cdc.gov/infectioncontrol/guidelines/ssi/index.html accessed 15th March 2019
2. Haley RW, Culver DH, White JW, et al. The nation-wide nosocomial infection rate: a new need for vital statistics. Am J Epidemiology 1985; 121: 159- 167 Epidemiol 1985;121:159-167.
3. Horan TC, Culver DH, Gaynes RP, et al. Nosocomial infections in surgical patients in the United States, January 1986–June 1992. Infect Control Hosp Epidemiology 1993; 14:73-80
4. Jarvis WR. Selected aspects of the socioeconomic impact of nosocomial infections: morbidity, mortality, cost, and prevention. Infect Control Hosp Epidemiology 1996; 17:552- 557 Epidemiol 1996;17:552-557
5. Lee J, Singletary R, Schmader K, et al: Surgical site infection in the elderly following orthopaedic surgery. Risk factors and outcomes. J Bone Joint Surg Am 2006; 88:1705-1712
6. Greene LR: Guide to the elimination of Orthopaedic surgery surgical site infections: An executive summary of the Association for Professionals in Infection Control and Epidemiology elimination guide. Am J Infect Control 2012; 40:384-386
7. Whitehouse JD, Friedman D, Kirkland KB, et al. The impact of surgical site infections following orthopaedic surgery at a community hospital and a university hospital: Adverse quality of life, excess length of stay and extra costs. Inf Control & Hosp Epidemiology 2002; 23: 183- 189.


How to Cite this article: Zaveri G. Surgical Site Infections in Orthopaedics: An Introduction. Journal of Clinical Orthopaedics July-Dec 2019;4(2):5-6.

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Diagnosis of Surgical Site Infection

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:12-16 | Dr. Manish Kothari


Author: Dr. Manish Kothari [1]

[1] Consultant Spine Surgeon, Jaslok Hospital & Research Centre, Mumbai

Address of Correspondence
Dr. Manish Kothari
Jaslok Hospital & Research Centre, Mumbai
E-mail: dr.manish.kothari@jaslokhospital.net


Abstract

Diagnosis of Surgical site infection is one of the most important factors that determines the further management of SSI. The diagnosis is based on various factors including clinical, laboratory investigations, Radiology, Bacteriology and molecular modalities. The current review summarises the salient features in all modalities.
Keywords: Surgical Site infection, Diagnosis.


References

1. Harrop JS, Styliaras JC, Ooi JC, Radcliff KE, Vaccaro AR, Wu C. Contributing factors to surgical site infections. J Am Acad Ortho Surg. 2012; 20(2):94-101.
2. WHO document on Global Guidelines For the Prevention of Surgical Site Infection. WHO Guidelines Development Group; Geneva, Switzerland; 2016;58-177
3. Guideline for Prevention of Surgical Site Infection (2017). Centre for disease control and prevention. https://www.cdc.gov/infectioncontrol/guidelines/ssi/index.html accessed 15th March 2019.
4. Simodynes, EE, Cochran, RM. Aeromonas hydrophila infection complicating an open tibial fracture. A case report. Clin OrthopRelat Res 1982; 171: 117–120
5. Levitsky KA, Hozack WJ, Balderston RA, et al. Evaluation of the painful prosthetic joint. Relative value of bone scan, sedimentation rate, and joint aspiration. J Arthroplasty. 1991;6:237–244.
6. Schinsky MF, Della Valle CJ, Sporer SM, et al. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008;90:1869–1875. doi: 10.2106/JBJS.G.01255.
7. Spangehl MJ, Masri BA, O’Connell JX, et al. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg Am. 1999;81:672–683.
8. Bilgen O, Atici T, Durak K, et al. C-reactive protein values and erythrocyte sedimentation rates after total hip and total knee arthroplasty. J Int Med Res. 2001;29:7–12.
9. Park KK, Kim TK, Chang CB, et al. Normative temporal values of CRP and ESR in unilateral and staged bilateral TKA. Clin OrthopRelat Res. 2008;466:179–188. doi: 10.1007/s11999-007-0001-x. [PMC free article]
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25. Schinsky, M.F.; Della Valle, C.J.; Sporer, S.M.; Paprosky, W.G. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J. Bone Jt. Surg. Ser. A 2008, 90, 1869–1875.
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How to Cite this article: Kothari M. Diagnosis of surgical site infection. Journal of Clinical Orthopaedics July-Dec 2019;4(2):12-16.

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Preventive Strategy for Surgical Site Infections in Orthopaedics

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:51-56 | Dr. Anoop C. Dhamangaonkar


Author: Dr. Anoop C. Dhamangaonkar [1]

[1] Department of Orthopaedics, LTMGH, Mumbai

Address of Correspondence
Dr. Anoop C. Dhamangaonkar,
Department of Orthopaedics, LTMGH, Mumbai


Abstract

Surgical site infections are serious complication of any surgery. There are many factors that affect the incidence of surgical site infections and if these factors are understood and controlled to a certain extent, it will help in reducing the incidence of SSIs. In current review, an overview of patient factors, Operative set up and intraoperative precautions are presented which will help in understanding and preventing SSIs.
Keywords: Surgical site infection, Orthoapedics, Prevention.


References

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How to Cite this article: Dhamangaonkar A C. Preventive Strategy for Surgical Site Infections in Orthopaedics. Journal of Clinical Orthopaedics July-Dec 2019;4(2):51-56.

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Surgical Site Infections in Orthopaedics: Epidemiology & Microbiology

Journal of Clinical Orthopaedics | Vol 4 | Issue 2 |  July-Dec 2019 | page:7-11 | Dr. Kedar Deogaonkar, Aditya Menon, Gautam Zaveri


Author: Dr. Kedar Deogaonkar [1], Aditya Menon [2], Gautam Zaveri [3]

[1] Department of Spine Surgery, Jaslok Hospital & Research Centre.

Address of Correspondence
Dr. Gautam Zaveri,
Department of Spine Surgery, Jaslok Hospital & Research Centre
E-mail: gautamzaveri1969@gmail.com


Abstract

Surgical site infections are one of the most common nosocomial infections. understanding epidemiology and microbiology of SSI will help in defining the problem and developing stratergies for prevention and management
Keywords: Surgical Site infection, Diagnosis.


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How to Cite this article: Deogaonkar K, Menon A, Zaveri G. Surgical Site Infections in Orthopaedics: Epidemiology & Microbiology. Journal of Clinical Orthopaedics July-Dec 2019;4(2):7-11.

(Abstract    Full Text HTML)   (Download PDF)