Dr. Ikjot Singh, Department of Orthopaedics, SGRDIMSAR Vallah, Amritsar – 143 001, Punjab, India E-mail: ikjothmm123@gmail.com
Abstract
Background Adhesive capsulitis (frozen shoulder) is a chronic musculoskeletal disorder associated with significant functional disability. Increasing evidence links this condition with metabolic disorders, particularly diabetes mellitus and pre-diabetes. However, the frequency of dysglycaemia in patients presenting with adhesive capsulitis remains understudied in the North Indian population. This study aimed to determine the frequency of pre-diabetes and diabetes in patients with adhesive capsulitis and to evaluate shoulder range of motion in relation to glycaemic status.
Methods A hospital-based cross-sectional study was conducted at the Department of Orthopaedics, SGRD Hospital, Vallah, Amritsar, from July 2024 to December 2025. One hundred consecutive patients with adhesive capsulitis (non-traumatic shoulder stiffness, restriction in ≥2 planes, age >18 years) were enrolled after written informed consent. Glycosylated haemoglobin (HbA1c) was estimated using the D10-HPLC method and classified per American Diabetes Association 2023 criteria as normoglycaemic (4.5–5.6%), pre-diabetic (5.7–6.4%), or diabetic (≥6.5%). Shoulder range of motion (flexion, abduction, external rotation in abduction and adduction) was measured by goniometry. One-way ANOVA was applied; p<0.05 was considered statistically significant.
Results The 51–60-year age group was most affected (37%), with a mean age of 56.3 years. A marked female preponderance was noted (67% vs. 33%). HbA1c revealed 44% diabetic, 26% pre-diabetic, and 30% normoglycaemic patients, yielding a combined dysglycaemia prevalence of 70%. Only 37% had a known prior diagnosis of diabetes; the remaining dysglycaemic cases were newly detected. Most patients (49%) presented within 3–6 months of symptom onset. ANOVA showed no statistically significant differences in shoulder flexion (p=0.654), abduction (p=0.578), external rotation in abduction (p=0.340), or external rotation in adduction (p=0.340) across glycaemic categories.
Conclusions Seventy percent of patients with adhesive capsulitis demonstrated impaired glucose metabolism, with a substantial proportion being previously undiagnosed. Routine HbA1c screening is recommended for all patients presenting with frozen shoulder. Glycaemic status did not significantly influence the degree of shoulder motion restriction at presentation, suggesting hyperglycaemia contributes to disease initiation rather than modulating acute clinical severity.
Keywords: Adhesive capsulitis, frozen shoulder, diabetes mellitus; pre-diabetes, HbA1c, glycosylated haemoglobin, range of motion, dysglycaemia
References
- 1. Akbar M, McLean M, Garcia-Melchor E, Crowe LA, McMillan P, Fazzi UG, et al. Fibroblast activation and inflammation in frozen shoulder. PLoS One. 2019;14:e0215301. [Google Scholar]
- 2. Andronic O, Ernstbrunner L, Jüngel A, Wieser K, Bouaicha S. Biomarkers associated with idiopathic frozen shoulder: a systematic review. Connect Tissue Res. 2019;61:1–8. [Google Scholar]
- 3. Le HV, Lee SJ, Nazarian A, Rodriguez EK. Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. 2017;9(2):75–84. [Google Scholar]
- 4. Cucchi D, Marmotti A, De Giorgi S, Bonaspetti G, Massazza G, Randelli P. Risk factors for shoulder stiffness: current concepts. Joints. 2017;5:217–23. [Google Scholar]
- 5. Dyer BP, Burton C, Rathod-Mistry T, Blagojevic-Bucknall M, van der Windt DA. Diabetes as a prognostic factor in frozen shoulder: a systematic review. Arch Rehabil Res Clin Transl. 2021;3(3):100141. [Google Scholar]
- 6. Cho CH, Song KS, Kim BS, Kim DH, Lho YM. Biological aspect of pathophysiology for frozen shoulder. BioMed Res Int. 2018;2018:1–8. [Google Scholar]
- 7. Chawla A, Chawla R, Jaggi S. Microvascular and macrovascular complications in diabetes mellitus: distinct or continuum? Indian J Endocrinol Metab. 2016;20(4):546–51. [Google Scholar]
- 8. Cher JZB, Akbar M, Kitson S, Crowe LAN, Garcia-Melchor E, Hannah SC, et al. Alarmins in frozen shoulder: a molecular association between inflammation and pain. Am J Sports Med. 2018;46:671–8. [Google Scholar]
- 9. Hsu CL, Sheu WHH. Diabetes and shoulder disorders. J Diabetes Investig. 2016;7:649–51. [Google Scholar]
- 10. Safran O, El-Haj M, Leibowitz G, Beyth S, Furman Z, Milgrom C, et al. Should patients with frozen shoulder be screened for diabetes mellitus? Orthop J Sports Med. 2017;5(7):2325967117716450. [Google Scholar]
- 11. Hassankhani EG, Pettersson H, Hassankhani SG, Hassankhani GG. Prevalence of diabetes and its effect on the course and treatment of frozen shoulder. Open J Orthop. 2022;12(12):463–73. [Google Scholar]
- 12. Pandey V, Aier S, Agarwal S, Sandhu AS, Murali SD. Prevalence of prediabetes in patients with idiopathic frozen shoulder: a prospective study. JSES Int. 2024;8(1):85–9. [Google Scholar]
- 13. Huang YP, Fann CY, Chiu YH, Yen MF, Chen LS, Chen HH, et al. Association of diabetes mellitus with the risk of developing adhesive capsulitis of the shoulder: a longitudinal population-based follow-up study. Arthritis Care Res. 2013;65(7):1197–202. [Google Scholar]
- 14. Mello DP, Corbin JN, Holanda LS, Pascarelli L, Nishimura EM, Almeida TB. Incidence and epidemiology of adhesive capsulitis during the COVID-19 pandemic. Acta Ortop Bras. 2023;31:e261132. [Google Scholar]
- 15. Kingston K, Curry EJ, Galvin JW, Li X. Shoulder adhesive capsulitis: epidemiology and predictors of surgery. J Shoulder Elbow Surg. 2018;27(8):1437–43. [Google Scholar]
- 16. Jacob L, Gyasi RM, Koyanagi A, Haro JM, Smith L, Kostev K. Prevalence of and risk factors for adhesive capsulitis of the shoulder in older adults from Germany. J Clin Med. 2023;12(2):669. [Google Scholar]
- 17. Kim JH, Kim BS, Han KD, Kwon HS. The risk of shoulder adhesive capsulitis in individuals with prediabetes and type 2 diabetes mellitus: a longitudinal nationwide population-based study. Diabetes Metab J. 2023;47(6):869–78. [Google Scholar]
- 18. Butt NI, Ghoauri MS, Waris U, Sabeh D, Qaisar F, Imran A. Prevalence of adhesive capsulitis in patients with type 2 diabetes mellitus: a single-center cross-sectional study from Pakistan. Cureus. 2024;16(10):e71200. [Google Scholar]
- 19. Zreik NH, Malik RA, Charalambous CP. Adhesive capsulitis of the shoulder and diabetes: a meta-analysis of prevalence. Muscles Ligaments Tendons J. 2016;6(1):26–34. [Google Scholar]
- 20. Millar NL, Meakins A, Struyf F, Willmore E, Campbell AL, Kirwan PD, et al. Frozen shoulder. Nat Rev Dis Primers. 2022;8(1):59. [Google Scholar]
- 21. Pandey V, Madi S. Clinical guidelines in the management of frozen shoulder: an update! Indian J Orthop. 2021;55(2):299–309. [Google Scholar]
- 22. Balci N, Balci MK, Tüzüner S. Shoulder adhesive capsulitis and shoulder range of motion in type II diabetes mellitus: association with diabetic complications. J Diabetes Complications. 1999;13(3):135–40. [Google Scholar]
- 23. Tighe CB, Oakley WS Jr. The prevalence of a diabetic condition and adhesive capsulitis of the shoulder. South Med J. 2008;101(6):591–5. [Google Scholar]
- 24. Bhise S, Nandanwar AY, Borkar S, Nawdikar G, Kulthe S, Patil S. Prevalence of diabetes mellitus in adhesive capsulitis of the shoulder: a cross-sectional study in a tertiary care centre. MIMER Med J. 2021;5(2):52–8. [Google Scholar]
- 25. Chan JH, Ho BS, Alvi HM, Saltzman MD, Marra G. The relationship between the incidence of adhesive capsulitis and hemoglobin A1c. J Shoulder Elbow Surg. 2017;26(10):1834–7. [Google Scholar]
- 26. Inayat F, Ali NS, Shahid H, Younus F. Prevalence and determinants of frozen shoulder in patients with diabetes: a single-center experience from Pakistan. Cureus. 2017;9(8):e1544. [Google Scholar]
- 27. Rai SK, Kashid M, Chakrabarty B, Upreti V, Shaki O. Is it necessary to screen patients with adhesive capsulitis of the shoulder for diabetes mellitus? J Family Med Prim Care. 2019;8(9):2927–32. [Google Scholar]
- 28. Akhuand MA, Tunio SA, Tunio ZH, Siyal S, Memon GA, Shah SM, et al. Frequency of frozen shoulder amongst T2DM patients. J Peoples Univ Med Health Sci Nawabshah. 2020;10(3):180–5. [Google Scholar]
- 29. Younas S, Fatima A. Comparison of shoulder pain, disability and range of motion in diabetic and non-diabetic patients with frozen shoulder. Khyber Med Univ J. 2020;12(3):221–4. [Google Scholar]
- 30. Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, et al. A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor. PLoS Genet. 2021;17(6):e1009577. [Google Scholar]
- 31. Mittal P, Goel Y, Dutta S, Giri S, Verma S, Gadre S, et al. A study on prevalence of adhesive capsulitis in patients with diabetes mellitus. J Curr Med Res Opin. 2022;5(06):1216–34. [Google Scholar]
- 32. Hussein N, Bartels M, Thomas M, Prince D. Incidence of diabetes mellitus type II and pre-diabetes among shoulder impingement syndrome patients and related modifying factors. Int J Phys Med Rehabil. 2021;9:604. [Google Scholar]
- 33. Dyer BP, Rathod-Mistry T, Burton C, Van Der Windt D, Bucknall M. Diabetes as a risk factor for the onset of frozen shoulder: a systematic review and meta-analysis. BMJ Open. 2023;13(1):e062377. [Google Scholar]
- 34. Zubair M, Saleem SA, Iqbal S, Durrani NA, ul Hasan N, Ali H. Likelihood of diabetes mellitus associated with frozen shoulder. J Fatima Jinnah Med Univ. 2023;17(2):79–83. [Google Scholar]
- 35. Albaker AB, Mishiming OS, Alharbi DM, Mazyad M, Alenazi SA, Alqarni AO, et al. Prevalence of frozen shoulder among diabetic patients in Western region of Saudi Arabia. Med Sci. 2023;27:e127ms2903. [Google Scholar]
- 36. Chen MH, Chen WS. A narrative review of adhesive capsulitis with diabetes. J Clin Med. 2024;13(19):5696. [Google Scholar]
- 37. Sun G, Li Q, Yin Y, Fu W, He K, Pen X. Risk factors and predictive models for frozen shoulder. Sci Rep. 2024;14(1):15261. [Google Scholar]
- 38. Dyer BP, Burton C, Rathod-Mistry T, Blagojevic-Bucknall M, van der Windt DA. Are patients with newly diagnosed frozen shoulder more likely to be diagnosed with type 2 diabetes? A cohort study in UK electronic health records. Diabetes Obes Metab. 2024;26(12):5915–21. [Google Scholar]
- 39. Tombak Y. Do comorbidities and body mass index influence shoulder pain, disability and joint range of motion? J Clin Med Kazakhstan. 2024;21(4):52–8. [Google Scholar]
- 40. Mahmoud TH, El-Sayed MS, Abdelnaeem WG. Association between frozen shoulder and diabetes mellitus: a narrative review. Deraya Int J Med Sci Rehabil. 2025;1(1):1–12. [Google Scholar]
- 41. Sarasua SM, Floyd S, Bridges WC, Pill SG. The epidemiology and etiology of adhesive capsulitis in the US Medicare population. BMC Musculoskelet Disord. 2021;22(1):828. [Google Scholar]
- 42. Drakes S, Aboulhosn P, Pham Y, Iuso A, Morgan K. Adhesive capsulitis: review of current concepts. Curr Phys Med Rehabil Rep. 2025;13(1):1–9. [Google Scholar]
- 43. Seher Z, Goher N, Hamid A, Latif U, Bukhari A, Rafique H, et al. Prevalence of adhesive capsulitis among diabetics and non-diabetics with shoulder pain in general population. Pak J Health Sci. 2023;4(6):67–71. [Google Scholar]
- 44. Sahu M, Ilias M, Pandey R, Saxena S, Saad T, Mishra N. Prevalence of frozen shoulder among diabetes patients: a cross-sectional study at a tertiary care center. J Pharm Bioallied Sci. 2024;16(Suppl 4):S3601–S3603. [Google Scholar]
- 45. Thomas D, Seeman T, Potter A, Hu P, Crimmins E, Sumantri C, et al. HPLC-based measurement of glycated haemoglobin using dried blood spots collected under adverse field conditions. Biodemography Soc Biol. 2018;64(1):43–62. [Google Scholar]
- 46. ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. Classification and diagnosis of diabetes: Standards of care in diabetes—2023. Diabetes Care. 2023;46(Suppl 1):S19–40. [Google Scholar]
- 47. Li W, Lou J, Huangfu W, Han D. Association between diabetes mellitus and adhesive capsulitis of shoulder: a 2-sample Mendelian randomization study. Medicine (Baltimore). 2025;104(35):e44119. [Google Scholar]