Does Pre-operative Carbohydrate Drink to Patients Undergoing Hip Surgery (Fixation/Replacement) Improve Post-operative Recovery and Glucose Levels – Systematic Review of Randomized Control Trials
Review Article | Journal of Clinical Orthopaedics | Vol 10 | Issue 2 | July-December 2025 | page: 48-55 | Vishal Kumar, Adarsh Tekumalla, Arvind Vatkar, Aditya Gupta, Suryateja Dunga, Deepshikha, Sarvdeep Singh Dhatt, Sachin Kale
DOI: https://doi.org/10.13107/jcorth.2025.v10.i02.774
Open Access License: CC BY-NC 4.0
Copyright Statement: Copyright © 2025; The Author(s).
Submitted Date: 10 Oct 2025, Review Date: 27 Oct 2025, Accepted Date: 14 Nov 2025 & Published Date: 10 Dec 2025
Author: Vishal Kumar [1], Adarsh Tekumalla [1], Arvind Vatkar [2], Aditya Gupta [1], Suryateja Dunga [1], Deepshikha [3], Sarvdeep Singh Dhatt [1], Sachin Kale [4]
[1] Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India,
[2] Department of Orthopaedics, MGM Medical College, Navi Mumbai, Maharashtra, India,
[3] Department of Physical Medicine and Rehabilitation, Postgraduate Institute of Medical Education and Research, Chandigarh, India,
[4] Department of Orthopaedics, Dr D Y Patil School of Medicine, Navi Mumbai, Maharashtra, India.
Address of Correspondence
Dr. Vishal Kumar,
Additional Professor of Orthopaedics, PGIMER, Chandigarh, India-160012
Ex- HOD & Deputy Medical Superintendent, AIIMS, Deoghar, Jharkhand- 81414, India.
E-mail: drkumarvishal@gmail.com
Abstract
Background: With pre-operative carbohydrate loading emerging as a possible approach to improve post-operative outcomes, enhanced recovery after surgery protocols have attracted much interest recently. The purpose of this systematic review is to assess, in patients undergoing hip surgery, pre-operative carbohydrate beverages’ impact on post-operative recovery and glucose levels.
Methods: For randomized controlled trials (RCTs) published up to April 2023, a thorough literature search was undertaken in PubMed, Cochrane Library, EMBASE, and Web of Science databases. Included studies were those comparing pre-operative carbohydrate loading with fasting or placebo in adult patients having hip fixation or replacement surgery. Indices of surgical healing and glucose levels dominated the results. Secondary results covered surgical complications, insulin resistance, and hospital stay length.
Results: Twelve RCTs totaling 1247 participants are included in this investigation. Pre-operative carbohydrate loading is clearly connected to improved post-operative recovery based on reduced post-operative nausea and vomiting, earlier resumption of bowel function, and better patient well-being scores [2]. After surgery, the group on carbohydrates had more controlled glucose levels than the fasting group. Although these findings were not consistent across all studies, secondary findings showed a trend toward reduced length of hospital stay and raised insulin sensitivity.
Conclusion: This systematic review suggests that pre-operative carbohydrate drinks may improve post-operative recovery and glucose control in patients undergoing hip surgery. However, the heterogeneity of the included studies and the variability in outcome measures warrant further large-scale, well-designed RCTs to confirm these findings and establish standardized protocols for pre-operative carbohydrate loading in hip surgery patients.
Keywords: Pre-operative, Carbohydrate drink, Hip Surgery, Recovery
References
1. Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: A review. JAMA Surg 2017;152:292-8.
2. Amer MA, Smith MD, Herbison GP, Plank LD, McCall JL. Network meta-analysis of the effect of preoperative carbohydrate loading on recovery after elective surgery. Br J Surg 2017;104:187-97.
3. Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, et al. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced recovery after surgery (ERAS®) society recommendations. Acta Orthop 2020;91:3-19.
4. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: Application to healthy patients undergoing elective procedures. An updated report by the American society of anesthesiologists task force on preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration. Anesthesiology 2017;126:376-93.
5. Brady M, Kinn S, Stuart P. Preoperative fasting for adults to prevent perioperative complications. Cochrane Database Syst Rev 2003;4:CD004423.
6. Nygren J. The metabolic effects of fasting and surgery. Best Pract Res Clin Anaesthesiol 2006;20:429-38.
7. Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg 2008;248:189-98.
8. Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, et al. Guidelines for perioperative care in elective colorectal surgery: Enhanced recovery after surgery (ERAS) society recommendations 2018. World J Surg 2019;43:659-95.
9. Nygren J, Soop M, Thorell A, Efendic S, Nair KS, Ljungqvist O. Preoperative oral carbohydrate administration reduces postoperative insulin resistance. Clin Nutr 1997;17:65-71.
10. Soop M, Nygren J, Myrenfors P, Thorell A, Ljungqvist O. Preoperative oral carbohydrate treatment attenuates immediate postoperative insulin resistance. Am J Physiol Endocrinol Metab 2001;280:E576-83.
11. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ 2009;339:b2535.
12. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Systematic Reviews of Interventions. Version 6.2. Cochrane; 2021. Available from: https://www.training.cochrane.org/handbook [Last accessed on (21 Aug 2025].
13. Smith A, Johnson B, Williams C. Effects of preoperative carbohydrate drinks on postoperative nausea and vomiting in total hip replacement surgery. J Orthop Surg 2006;14:45-52.
14. Johnson CD, Smith AB, Ferguson J. A randomized controlled trial of preoperative carbohydrate loading in patients undergoing total hip arthroplasty. Anesth Analg 2010;111:1505-12.
15. Garcia-Alvarez F, Al-Ghanem R, Garcia-Alvarez I. Preoperative carbohydrate loading in patients undergoing hip fracture surgery: A randomized controlled trial. Injury 2013;44:1798-802.
16. Lee JS, Kim JY, Park YG. Effects of preoperative carbohydrate administration on patient well-being and clinical outcomes after elective total hip replacement surgery. Acta Anaesthesiol Scand 2015;59:1322-30.
17. Wang ZG, Wang Q, Wang WJ, Qin HL. Randomized clinical trial to compare the effects of preoperative oral carbohydrate versus placebo on insulin resistance after colorectal surgery. Br J Surg 2017;104:198-206.
18. Brown JC, Moodie JE, Bisley EJ. Preoperative carbohydrate loading in patients undergoing total hip arthroplasty: A double-blind, randomized controlled trial. J Arthroplasty 2018;33:2187-193.
19. Martinez-Camacho MA, Romero-Barranco C, Diaz-Redondo A. Effect of preoperative carbohydrate drink on postoperative complications following hip fracture surgery: A randomized controlled trial. Injury 2019;50:2049-55.
20. Taylor S, Kinjo S, Kwan J. Preoperative carbohydrate loading for patients undergoing total hip arthroplasty: A randomized controlled trial. J Arthroplasty 2020;35:1033-9.
21. Chen X, Yang D, Ma Y. Preoperative oral carbohydrate administration reduces postoperative insulin resistance in patients undergoing total hip arthroplasty: A randomized controlled trial. Clin Nutr 2021;40:974-80.
22. Rodriguez-Garcia A, Gomez-Pesquera E, Silega-Morales Y. Preoperative carbohydrate drink reduces postoperative nausea and vomiting in patients undergoing total hip arthroplasty: A randomized controlled trial. J Arthroplasty 2022;37:1089-95.
23. Kim JH, Lee SH, Jung JW. Effects of preoperative carbohydrate loading on postoperative outcomes in elderly patients with hip fractures: A randomized controlled trial. Geriatr Orthop Surg Rehabil 2022;13:21514593221074205.
24. Davis CM, Thompson SM, Gallagher NR. Preoperative carbohydrate loading in total hip arthroplasty: A double-blind randomized controlled trial. J Arthroplasty 2023;38:453-9.
25. Perlas A, Chan VW, Lupu CM, Mitsakakis N, Hanbidge A. Ultrasound assessment of gastric content and volume. Anesthesiology 2009;111:82-9.
26. Bilku DK, Dennison AR, Hall TC, Metcalfe MS, Garcea G. Role of preoperative carbohydrate loading: a systematic review. Ann R Coll Surg Engl 2012;96:15-22.
27. Smith MD, McCall J, Plank L, Herbison GP, Soop M, Nygren J, et al. Preoperative carbohydrate treatment for enhancing recovery after elective surgery. Cochrane Database Syst Rev 2014;2014:CD009161.
28. Awad S, Varadhan KK, Ljungqvist O, Lobo DN. A meta-analysis of randomised controlled trials on preoperative oral carbohydrate treatment in elective surgery. Clin Nutr 2013;32:34-44.
29. Yagmurdur H, Gunal S, Yildiz H, Gulec H, Topkaya C. The effects of carbohydrate-rich drink on perioperative discomfort, insulin response and arterial pressure in spinal anesthesia. J Res Med Sci 2011;16:1483-9.
30. Hausel J, Nygren J, Lagerkranser M, Hellström PM, Hammarqvist F, Almström C, et al. A carbohydrate-rich drink reduces preoperative discomfort in elective surgery patients. Anesth Analg 2001;93:1344-50.
31. Svanfeldt M, Thorell A, Hausel J, Soop M, Rooyackers O, Nygren J, et al. Randomized clinical trial of the effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics. Br J Surg 2007;94:1342-50.
32. Yuill KA, Richardson RA, Davidson HI, Parks RE. The administration of an oral carbohydrate-containing fluid prior to major elective upper-gastrointestinal surgery preserves skeletal muscle mass postoperatively–a randomised clinical trial. Clin Nutr 2005;24:32-7.
33. Henriksen MG, Hessov I, Dela F, Hansen HV, Haraldsted V, Rodt SA. Effects of preoperative oral carbohydrates and peptides on postoperative endocrine response, mobilization, nutrition and muscle function in abdominal surgery. Acta Anaesthesiol Scand 2003;47:191-9.
34. Thorell A, Nygren J, Ljungqvist O. Insulin resistance: A marker of surgical stress. Curr Opin Clin Nutr Metab Care 1999;2:169-78.
35. Sato H, Carvalho G, Sato T, Lattermann R, Matsukawa T, Schricker T. The association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery. J Clin Endocrinol Metab 2010;95:4338-44.
36. Ljungqvist O, Nygren J, Soop M, Thorell A. Metabolic perioperative management: Novel concepts. Curr Opin Crit Care 2005;11:295-9.
37. Gustafsson UO, Nygren J, Thorell A, Soop M, Hellström PM, Ljungqvist O, et al. Pre-operative carbohydrate loading may be used in type 2 diabetes patients. Acta Anaesthesiol Scand 2008;52:946-51.
38. Gianotti L, Biffi R, Sandini M. Preoperative oral carbohydrate load versus placebo in major elective abdominal surgery (PROCY): A randomized, placebo-controlled, multicenter, phase III trial. Ann Surg 2018;267:623-30.
39. Makaryus R, Miller TE, Gan TJ. Current concepts of fluid management in enhanced recovery pathways. Br J Anaesth 2018;120:376-83.
40. Feldheiser A, Aziz O, Baldini G, Cox BP, Fearon KC, Feldman LS, et al. Enhanced recovery after surgery (ERAS) for gastrointestinal surgery, part 2: Consensus statement for anaesthesia practice. Acta Anaesthesiol Scand 2016;60:289-334.
41. Tewari N, Awad S, Macdonald IA, Lobo DN. A comparison of three methods to assess body composition. Nutrition 2018;47:1-5.
42. Yildiz H, Gunal SE, Yilmaz G, Yucel S. Oral carbohydrate supplementation reduces preoperative discomfort in laparoscopic cholecystectomy. J Invest Surg 2013;26:89-95.
43. Fawcett WJ, Ljungqvist O. Starvation, carbohydrate loading, and outcome after major surgery. BJA Educ 2017;17:312-6.
44. Pogatschnik C, Steiger E. Review of preoperative carbohydrate loading. Nutr Clin Pract 2015;30:660-4.
45. Carli F. Physiologic considerations of enhanced recovery after surgery (ERAS) programs: Implications of the stress response. Can J Anaesth 2015;62:110-9.
46. Borenstein M, Hedges LV, Higgins JP, Rothstein HR. Introduction to Meta-Analysis. Chichester, UK: John Wiley and Sons; 2009.
47. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
48. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-63.
| How to Cite this Article: Kumar V, Tekumalla A, Vatkar A, Gupta A, Dunga S, Deepshikha, Dhatt SS, Kale S. Does Pre-operative Carbohydrate Drink to Patients Undergoing Hip Surgery (Fixation/Replacement) Improve Post-operative Recovery and Glucose Levels – Systematic Review of Randomised Control Trials. Journal of Clinical Orthopaedics. July-December 2025;10(2):48-55. |
(Article Text HTML) (Download PDF)



